Systemic lupus erythematosus-associated pulmonary hypertension: good outcome following sildenafil therapy
Identifieur interne : 002059 ( Main/Exploration ); précédent : 002058; suivant : 002060Systemic lupus erythematosus-associated pulmonary hypertension: good outcome following sildenafil therapy
Auteurs : J. Molina [Argentine] ; E. Lucero ; S. Luluaga [Argentine] ; V. Bellomio [Argentine] ; A. Spindler [Argentine] ; A. Berman [Argentine]Source :
- Lupus [ 0961-2033 ] ; 2003-04.
English descriptors
- Teeft :
- Bene cial, Cant, Case report, Clinical response, Congestive heart failure, Conventional therapy, Doppler, Doppler echocardiogram, Dos, Dyspnea, Echocardiogram, Erythematosus, Exercise tolerance, Functional class, Hemodynamic, Hypertension, Iloprost, Longterm reduction, Lupus, Mmhg, Oral sildena, Pasp, Persistent phenomenon, Pulmonary hypertension, Respir crit care, Right ventricle, Signi, Signi cant, Signi cant side effects, Sildena, Systemic lupus erythematosus, Vasodilator.
Abstract
A 46-year-old woman with systemic lupus erythematosus(SLE) and concomitant severe pulmonary hypertension (PH) is described. Other secondary causes of PH including thromboembolism, phospholipid syndrome, valvular disease and interstitial pulmonary involvement were ruled out. Owing to her lack of clinical response to conventional therapy, sildenafil was begun at increasing doses up to 400 mg daily. Both clinical and hemodynamic improvement ensued. This appears to be the first clinical report of the use of sildenafil in SLE followed by resolution of severe PH.
Url:
DOI: 10.1191/0961203303lu324cr
Affiliations:
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Other secondary causes of PH including thromboembolism, phospholipid syndrome, valvular disease and interstitial pulmonary involvement were ruled out. Owing to her lack of clinical response to conventional therapy, sildenafil was begun at increasing doses up to 400 mg daily. Both clinical and hemodynamic improvement ensued. This appears to be the first clinical report of the use of sildenafil in SLE followed by resolution of severe PH.</div></front></TEI><affiliations><list><country><li>Argentine</li></country></list><tree><noCountry><name sortKey="Lucero, E" sort="Lucero, E" uniqKey="Lucero E" first="E" last="Lucero">E. Lucero</name></noCountry><country name="Argentine"><noRegion><name sortKey="Molina, J" sort="Molina, J" uniqKey="Molina J" first="J" last="Molina">J. Molina</name></noRegion><name sortKey="Bellomio, V" sort="Bellomio, V" uniqKey="Bellomio V" first="V" last="Bellomio">V. Bellomio</name><name sortKey="Berman, A" sort="Berman, A" uniqKey="Berman A" first="A" last="Berman">A. Berman</name><name sortKey="Luluaga, S" sort="Luluaga, S" uniqKey="Luluaga S" first="S" last="Luluaga">S. Luluaga</name><name sortKey="Spindler, A" sort="Spindler, A" uniqKey="Spindler A" first="A" last="Spindler">A. Spindler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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